Will humans hibernate? (in Dutch)
On the occason of his PhD graduation, Edwin discussess how hibernators avoid blood clotting and the potential benefits to humans
Rob Henning discusses benefits of human hibernation
Various scientists discuss the possibility of human hibernation, mechanisms and the potential benefits for
man, featuring Rob Henning from 20:14 onwards
Does hibernation help you to get a hundred years? - about combatting Alzheimer's disease, criminals and coagulation
Helpt winterslaap om 100 jaar te worden? - over het tegengaan van de ziekte van Alzheimer, criminelen en bloedstolling
Is een winterslaap ook goed voor mensen?
From hibernation to combatting free radicals
All the reasons you can't hibernate in winter
Prof. Rob Henning's TEDx lecture
The big sleep
Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Christine de Veij Mestdagh et al., 2024
Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction
Valeria Cogut et al., 2024
Safety, tolerability and toxicokinetics of the novel mitochondrial drug SUL-138 administered orally to rat and minipig
Daniël Swart et al., Toxicology Reports, 2024
Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver
Marloes Oosterhof et al., 2024
Mitochondrial Targeting against Alzheimer’s Disease: Lessons from Hibernation
Christine de Veij Mestdagh et al., 2024
Hibernation and hemostasis
Edwin de Vrij et al., 2023
Inhibition of Ferroptosis Enables Safe Rewarming of HEK293 Cells following Cooling in University of Wisconsin Cold Storage Solution
Lucas Gartzke et al., 2023
Liver transcriptomic and methylomic analyses identify transcriptional mitogen-activated protein kinase regulation in facultative hibernation of Syrian hamster
Louis Coussement et al., 2023
Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet
Sebastiaan Lambooy et al., 2023
GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide:Quinone Oxidoreductase in Endothelial Cells
Bastiaan Star et al., 2023
Temperature Effects on DNA Damage during Hibernation
Lauren de Wit et al., 2023
The hibernation‑derived compound SUL‑138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model
Christine de Veij Mestdagh et al., 2022
Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion
Marziyeh Tolouee et al., 2022
Mild hypothermia during cardiopulmonary bypass assisted CABG is associated with improved short- and long-term survival, a 18-year cohort study
Koen Hendriks et al., 2022
Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia
Dalibor Nakladal et al., 2022
Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease
Christina de Veij Mestdagh et al., 2021
Towards prevention of ischemia-reperfusion kidney injury: Pre-clinical evaluation of 6-chromanol derivatives and the lead compound SUL-138
Pieter Vogelaar et al., 2021
Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation
Itamar Dias et al., 2021
Phase specific suppression of neutrophil function in hibernating Syrian hamster
Vera Reitsema et al., 2021
The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms
Sylvain Giroud et al., 2021
Reversible thrombocytopenia during hibernation originates from storage and release of platelets in liver sinusoids
Edwin de Vrij et al., 2021
Hibernator-Derived Cells Show Superior Protection and Survival in Hypothermia Compared to Non-Hibernator Cells
Koen Hendriks et al., 2020
The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor
Dalibor Nakladal et al., 2019
Gasotransmitters in health and disease: a mitochondria-centered view
Koen Hendriks et al., 2019
Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation
Koen Hendriks et al., 2019
Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
Hanno Maassen et al., 2019
Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system
Marit Wiersma et al., 2018
The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats
Pieter Vogelaar et al., 2018
Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells
Koen Hendriks et al., 2017
Brain Inflammatory Cytokines And Microglia Morphology Changes Throughout Hibernation Phases In Syrian Hamster
Valeria Cogut et al., 2017
A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation?
George J. Dugbartey et al., 2017
The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells
Ghazaleh Hajmousa et al., 2017
The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice
Sebastian P.H. Lambooy et al., 2017
The influence of sex and diet on the characteristics of hibernation in Syrian hamsters
Marie Trefna et al., 2015
Neuroprotective hypothermia – Why keep your head cool during ischemia and reperfusion
Nienke Talma et al., 2015
Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes
George J. Dugbartey et al., 2015
Induction of a Torpor-Like State by 5’-AMP Does Not Depend on H2S Production
George J. Dugbartey et al., 2015
Platelet Dynamics during Natural and Pharmacologically Induced Torpor and Forced Hypothermia
Edwin L. de Vrij et al., 2014
Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide
Fatemeh Talaei et al., 2014
Hippocampal cystathionine beta synthase in young and aged mice
Jojanneke Bruintjes et al., 2014
Hydrogen sulfide restores a normal morphological phenotype in Wernersyndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway
Fatemeh Talaei et al., 2013
Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination
Hjalmar R. Bouma et al., 2013
5'-AMP impacts lymphocyte recirculation through activation of A2B receptors
Hjalmar R. Bouma et al., 2013
Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel
Hjalmar R. Bouma et al., 2013
Induction of VMAT-1 and TPH-1 Expression Induces Vesicular Accumulation of Serotonin and Protects Cells and Tissue from Cooling/Rewarming Injury
Fatemeh Talaei et al., 2012
The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster
Fatemeh Talaei et al., 2012
Induction of Torpor: Mimicking Natural Metabolic Suppression for Biomedical Applications
Hjalmar R. Bouma et al., 2012
Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/H2S Pathway
Fatemeh Talaei et al., 2011
Reversible remodeling of lung tissue during hibernation in the Syrian hamster
Fatemeh Talaei et al., 2011
Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate
Hjalmar R. Bouma et al., 2011
Blood cell dynamics during hibernation in the European Ground Squirrel
Hjalmar R. Bouma et al., 2010
AMP-Activated Protein Kinase as a Target for Preconditioning in Transplantation Medicine
Hjalmar R. Bouma et al., 2010
Hibernation: the immune system at rest?
Hjalmar R. Bouma et al., 2010
Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of hibernating ground squirrel
Maria Sandovici et al., 2004
Normalization of aortic function during arousal episodes in the hibernating ground squirrel
Rob H. Henning et al., 2002
Ideas and comments are welcomed
Department of Clinical Pharmacy and Pharmacology, AP50
University Medical Center Groningen
Hanzeplein 1, 9713 GZ Groningen, The Netherlands
+31 (50) 361 7870