Lecture Open University by Rob Henning

Will humans hibernate? (in Dutch)

Gaan mensen in winterslaap

Interview with Edwin de Vrij (in Dutch)

On the occason of his PhD graduation, Edwin discussess how hibernators avoid blood clotting and the potential benefits to humans

How to avoid blood clots

Interview Business News Radio (in Dutch)

Rob Henning discusses benefits of human hibernation

How to hibernate

Interview BBC radio 4

Various scientists discuss the possibility of human hibernation, mechanisms and the potential benefits for
man, featuring Rob Henning from 20:14 onwards

How to hibernate

Interview national Dutch TV with Ate Boerema, Maaike Goris \& Edwin de Vrij with Midas Dekker about hibernation- Het Ei van Midas

Does hibernation help you to get a hundred years? - about combatting Alzheimer's disease, criminals and coagulation
Helpt winterslaap om 100 jaar te worden? - over het tegengaan van de ziekte van Alzheimer, criminelen en bloedstolling

Interview national Dutch TV - EenVandaag

Is een winterslaap ook goed voor mensen?

Interview with Naked Scientists / BBC 5

From hibernation to combatting free radicals

Reasons you can't hibernate

Interview with BBC

All the reasons you can't hibernate in winter

Reasons you can't hibernate

TEDx lecture

Prof. Rob Henning's TEDx lecture

Frank Swain's report on the research of our team

The big sleep

The Big Sleep


This section includes most of our recent publications

Liver transcriptomic and methylomic analyses identify transcriptional mitogen-activated protein kinase regulation in facultative hibernation of Syrian hamster

Louis Coussement et al., 2023

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet

Sebastiaan Lambooy et al., 2023

GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide:Quinone Oxidoreductase in Endothelial Cells

Bastiaan Star et al., 2023

Temperature Effects on DNA Damage during Hibernation

Lauren de Wit et al., 2023

The hibernation‑derived compound SUL‑138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model

Christina de Veij Mestdagh et al., 2022

Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

Marziyeh Tolouee et al., 2022

Mild hypothermia during cardiopulmonary bypass assisted CABG is associated with improved short- and long-term survival, a 18-year cohort study

Koen Hendriks et al., 2022

Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

Dalibor Nakladal et al., 2022

Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease

Christina de Veij Mestdagh et al., 2021

Towards prevention of ischemia-reperfusion kidney injury: Pre-clinical evaluation of 6-chromanol derivatives and the lead compound SUL-138

Pieter Vogelaar et al., 2021

Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation

Itamar Dias et al., 2021

Phase specific suppression of neutrophil function in hibernating Syrian hamster

Vera Reitsema et al., 2021

The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms

Sylvain Giroud et al., 2021

Reversible thrombocytopenia during hibernation originates from storage and release of platelets in liver sinusoids

Edwin de Vrij et al., 2021

Hibernator-Derived Cells Show Superior Protection and Survival in Hypothermia Compared to Non-Hibernator Cells

Koen Hendriks et al., 2020

The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor

Dalibor Nakladal et al., 2019

Gasotransmitters in health and disease: a mitochondria-centered view

Koen Hendriks et al., 2019

Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

Koen Hendriks et al., 2019

Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys

Hanno Maassen et al., 2019

Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system

Marit Wiersma et al., 2018

The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats

Pieter Vogelaar et al., 2018

Differences in mitochondrial function and morphology during cooling and rewarming between hibernator and non-hibernator derived kidney epithelial cells

Koen Hendriks et al., 2017

Brain Inflammatory Cytokines And Microglia Morphology Changes Throughout Hibernation Phases In Syrian Hamster

Valeria Cogut et al., 2017

A Hibernation-Like State for Transplantable Organs: Is Hydrogen Sulfide Therapy the Future of Organ Preservation?

George J. Dugbartey et al., 2017

The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells

Ghazaleh Hajmousa et al., 2017

The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice

Sebastian P.H. Lambooy et al., 2017

The influence of sex and diet on the characteristics of hibernation in Syrian hamsters

Marie Trefna et al., 2015

Neuroprotective hypothermia – Why keep your head cool during ischemia and reperfusion

Nienke Talma et al., 2015

Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes

George J. Dugbartey et al., 2015

Induction of a Torpor-Like State by 5’-AMP Does Not Depend on H2S Production

George J. Dugbartey et al., 2015

Platelet Dynamics during Natural and Pharmacologically Induced Torpor and Forced Hypothermia

Edwin L. de Vrij et al., 2014

Increased protein aggregation in Zucker Diabetic Fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide

Fatemeh Talaei et al., 2014

Hippocampal cystathionine beta synthase in young and aged mice

Jojanneke Bruintjes et al., 2014

Hydrogen sulfide restores a normal morphological phenotype in Wernersyndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway

Fatemeh Talaei et al., 2013

Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination

Hjalmar R. Bouma et al., 2013

5'-AMP impacts lymphocyte recirculation through activation of A2B receptors

Hjalmar R. Bouma et al., 2013

Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel

Hjalmar R. Bouma et al., 2013

Induction of VMAT-1 and TPH-1 Expression Induces Vesicular Accumulation of Serotonin and Protects Cells and Tissue from Cooling/Rewarming Injury

Fatemeh Talaei et al., 2012

The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster

Fatemeh Talaei et al., 2012

Induction of Torpor: Mimicking Natural Metabolic Suppression for Biomedical Applications

Hjalmar R. Bouma et al., 2012

Serotonin and Dopamine Protect from Hypothermia/Rewarming Damage through the CBS/H2S Pathway

Fatemeh Talaei et al., 2011

Reversible remodeling of lung tissue during hibernation in the Syrian hamster

Fatemeh Talaei et al., 2011

Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate

Hjalmar R. Bouma et al., 2011

Blood cell dynamics during hibernation in the European Ground Squirrel

Hjalmar R. Bouma et al., 2010

AMP-Activated Protein Kinase as a Target for Preconditioning in Transplantation Medicine

Hjalmar R. Bouma et al., 2010

Hibernation: the immune system at rest?

Hjalmar R. Bouma et al., 2010

Differential regulation of glomerular and interstitial endothelial nitric oxide synthase expression in the kidney of hibernating ground squirrel

Maria Sandovici et al., 2004

Normalization of aortic function during arousal episodes in the hibernating ground squirrel

Rob H. Henning et al., 2002

Meet Our Team

Team Member
Professor of Pharmacology

Robert H. Henning

head of section of Pharmacology
Team Member

Hjalmar R. Bouma

Staff member
Team Member

Femke Hoogstra-Berends

Staff member
Team Member

Maaike Goris

Staff member

Some Fun Facts


Hours of Work


Hibernating species studied


Current number of PhD students


Awards Won

Let’s Discuss

Ideas and comments are welcomed

Professor Rob H. Henning

Department of Clinical Pharmacy and Pharmacology, AP50

University Medical Center Groningen

Hanzeplein 1, 9713 GZ Groningen, The Netherlands

+31 (50) 361 7870

Say hello!